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Data missing from the study variables will be treated with the direct likelihood method [ 34 ] when no data is available. The principal variables taken into account in calculating the size of sample needed are iron deficiency anemia, risk of hemoconcentration in the third trimester of pregnancy, and birth weight of the baby. Adapting iron dose supplementation in pregnancy for greater effectiveness on mother and child health: protocol of the ECLIPSES randomized clinical trial. Milman N, Hertz J: Pregnancy and iron prophylaxis — how and how much?. Search all BMC articles Search. Therefore the aims of the study are to determine the highest level of effectiveness of iron supplementation adapted to hemoglobin Hb levels in early pregnancy, which would be optimum for mother-child health.

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