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Granberg CF expert opinion. Although the cause of hypospadias is usually unknown, these factors may be associated with the condition:. Sometimes, hypospadias is genetic, but environment also may play a role. Hypospadias is common and doesn't cause difficulty in caring for your infant. Hypospadias hi-poe-SPAY-dee-us is a birth defect congenital condition in which the opening of the urethra is on the underside of the penis instead of at the tip. In most cases, the exact cause of hypospadias is unknown. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

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